Patient-side wound monitoring with multimodal sensor technology (WUMMS)

The WUMMS project is investigating a mobile, multimodal diagnostic platform with telemedicine connectivity for on-site analysis of chronic wounds. The platform to be developed combines the performance of laboratory-based molecular detection methods with the advantages of rapid tests.

Approximately 1% of the adult population in Germany suffers from a chronic wound. Current wound management places a high burden on the often multimorbid patient. Continuous monitoring of the wound status in the context of home care can improve this situation.

The WUMMS project deals with the development of new miniaturized actuator concepts (Memetis) for a portable and cost-effective device, the integration of multimodal biosensor technology in the test cartridge (Hahn-Schickard), and the research of new biomarkers for the assessment of wounds (Uniklinikum Freiburg). Multimodal electrochemical sensing allows the detection of several analyte classes with comparable functionalization of the detection electrodes. DNA is detected by DNA amplification reaction and proteins by aptamers (short DNA molecules). Aptamers will be optimized for integrity and reliable detection even in complex sample matrices (Aptamimetics).

In addition, the development of a digital interface will facilitate communication between the different actors involved in the wound care management, especially in rural areas.