Automated platform for selective organoid handling using AI (ADAPT-2)

The selective organoid handling platform (SpheroPro) developed in ADAPT will be extended in ADAPT-2 to include an AI-assisted selection of suitable 3D cell culture models and a 3D imaging module based on holographic tomography for non-invasive and label-free analysis of organoids and spheroids.

With ADAPT-2, an innovative microtumor handling platform is significantly advanced towards automation. The platform will be used to gently select and sort 3D microtumors of different genesis based on universally applicable protocols and animal-free approaches for applications in clinical diagnostics and to establish microtumor biobanks in drug development. The platform will be extended to include AI-assisted selection of suitable microtumors and a 3D imaging module based on holographic tomography for non-invasive and label-free analysis of microtumors. Using AI in combination with machine learning, a correlation of the in vitro data with clinical patient data will be established. The goal is to unify and link procedures used in personalized medicine and drug development through quality control, standardization and automation.